Author

A. M. Lerario

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

D. R. Mohan· 2 shared G. D. Hammer· 2 shared S. K. N. Marie· 2 shared T. J. Giordano· 2 shared A. A. Apfelbaum· 1 shared A. C. Latronico· 1 shared A. L. Solon· 1 shared A. Wakamatsu· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

D. R. Mohan

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ATE1 activates ER-stress and UPR pathways in glioblastoma

J. Macedo-da-Silva, S. M. Oba-Shinjo, L. Rosa-Fernandes, R. d. S. Soares, A. M. Lerario, I. F. Moretti, T. d. S. Laurentino, R. C. Cintra, S. K. N. Marie, G. Palmisano

This study investigates the role of ATE1-mediated N-terminal arginylation in glioblastoma, finding it activates ER-stress and UPR pathways, promotes autophagy, and supports tumor growth.

bioRxiv · Sep 25, 2023 · PreprintCancer Biology

Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth.

M. K. Penny, A. M. Lerario, K. J. Basham, S. Chukkapalli, Y. Yu, D. R. Mohan, C. LaPensee, K. Converso-Baran, M. Hoenerhoff, L. Suarez Fernandez, C. Gonzalez del Rey, T. J. Giordano, R. Han, E. A. Newman, G. D. Hammer

This paper identifies a Wnt/β-catenin-regulated extracellular matrix (ECM) program in adrenocortical carcinoma (ACC) that promotes tumor growth and shows that inhibiting this pathway reduces tumor viability and growth in preclinical models.

bioRxiv · Oct 23, 2022Cancer Biology

β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma

D. R. Mohan, K. S. Borges, I. Finco, C. R. LaPensee, J. Rege, A. L. Solon, D. W. Little, T. Else, M. Q. Almeida, D. Dang, J. Haggerty-Skeans, A. A. Apfelbaum, M. Vinco, A. Wakamatsu, B. M. P. Mariani, , G. D. Hammer

This study shows that β-catenin maintains adrenocortical carcinoma differentiation through chromatin and histone interactions, and that targeting EZH2 can disrupt this process and inhibit tumor growth.

bioRxiv · Jul 2, 2022 · PreprintCancer Biology