Author

L. Trusolino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

A. Bertotti· 3 shared A. Bardelli· 2 shared B. Lupo· 2 shared E. Grassi· 2 shared E. R. Zanella· 2 shared F. Cottino· 2 shared F. Galimi· 2 shared F. Sassi· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Bertotti

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer

E. Grassi, V. Vurchio, G. D. Cresswell, I. Catalano, B. Lupo, F. Sassi, F. Galimi, S. Borgato, M. Ferri, M. Viviani, S. Pompei, G. Urgese, B. Chen, E. R. Zanella, F. Cottino, , A. Bertotti

The paper measures mutation rates in microsatellite stable colorectal cancers and finds they vary between tumors and increase during metastasis.

bioRxiv · Feb 26, 2024Cancer Biology

XENTURION, a multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients for population-level translational oncology

S. M. Leto, E. Grassi, M. Avolio, V. Vurchio, F. Cottino, M. Ferri, E. R. Zanella, L. Di Blasio, D. Somale, M. Vara-Messler, F. Galimi, F. Sassi, B. Lupo, I. Catalano, M. Pinnelli, , L. Trusolino

XENTURION provides a resource of PDX models and tumoroids from metastatic CRC patients, revealing variable cetuximab responses and identifying therapeutic targets through cross-platform validation.

bioRxiv · Jul 10, 2023Cancer Biology

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

E. Gil Vazquez, N. Nasreddin, G. N. Valbuena, E. J. Mulholland, H. L. Belnoue-Davis, H. Eggington, R. O. Schenck, V. M. Wouters, P. Wirapati, K. Gilroy, T. R. M. Lannagan, D. J. Flanagan, A. K. Najumudeen, S. Omwenga, A. M. B. McCorry, , S. J. Leedham

The paper examines stem cell population dynamics in colorectal tumors, showing that CBC-RSC admixture correlates with mutations and microenvironmental changes, and is linked to chemoresistance.

bioRxiv · Jun 11, 2022Cancer Biology

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

G. Rospo, A. Lorenzato, N. Amirouchene-Angelozzi, A. Magri, C. Cancelliere, G. Corti, C. Negrino, V. Amodio, M. Montone, A. Bartolini, L. Barault, L. Novara, C. Isella, E. Medico, A. Bertotti, , A. Bardelli

This study tracks neoantigen profiles in colorectal cancers with DNA repair defects, finding dynamic patterns linked to antigen presentation downregulation and evolvability.

bioRxiv · Jun 11, 2019Cancer Biology