Author

D. J. Flanagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. K. Najumudeen· 2 shared A. C. Williams· 1 shared A. D. Campbell· 1 shared A. Easton· 1 shared A. J. Hoskin· 1 shared A. K. Holt· 1 shared A. M. B. McCorry· 1 shared D. J. Huels· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

A. K. Najumudeen

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2 papers

Recent·Most cited

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

A. K. Holt, A. K. Najumudeen, A. J. Hoskin, D. N. Legge, E. M. H. Mortensson, D. J. Flanagan, N. Jones, M. Kollareddy, T. J. Collard, P. Timms, O. J. Sansom, A. C. Williams, E. E. Vincent

This study shows aspirin reprograms colorectal cancer cell metabolism and increases sensitivity to glutaminase inhibition, suggesting potential for improved metabolic therapies in CRC.

bioRxiv · Aug 24, 2022Cancer Biology

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

E. Gil Vazquez, N. Nasreddin, G. N. Valbuena, E. J. Mulholland, H. L. Belnoue-Davis, H. Eggington, R. O. Schenck, V. M. Wouters, P. Wirapati, K. Gilroy, T. R. M. Lannagan, D. J. Flanagan, A. K. Najumudeen, S. Omwenga, A. M. B. McCorry, , S. J. Leedham

The paper examines stem cell population dynamics in colorectal tumors, showing that CBC-RSC admixture correlates with mutations and microenvironmental changes, and is linked to chemoresistance.

bioRxiv · Jun 11, 2022Cancer Biology