S. Pompei

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer

The paper measures mutation rates in microsatellite stable colorectal cancers and finds they vary between tumors and increase during metastasis.

Metacommunity Structure Preserves Genome Diversity in the Presence of Gene-specific Selective Sweeps.

The paper shows that metacommunities can maintain genome diversity despite gene-specific selective sweeps through mathematical modeling and simulations.

A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains

The paper develops a fitness model to explain the trade-offs in yeast aneuploids, showing how chromosome gains can be beneficial under stress but costly otherwise.

Adaptive ratchets and the evolution of molecular complexity

This study shows how molecular recognition sites can evolve to complex states by adapting to moving targets, increasing code length and reducing coding density through an adaptive ratchet mechanism.

Drug-induced colorectal cancer persister cells show increased mutation rate

The paper shows that drug treatment induces colorectal cancer persister cells with significantly increased mutation rates, suggesting new strategies to prevent tumor recurrence.

Epistasis, aneuploidy, and gain-of-function mutations underlie the evolution ofresistance to induced microtubule depolymerization

The paper evolves yeast populations with impaired microtubule polymerization and identifies mutations and chromosome duplications that confer resistance to microtubule depolymerizing drugs.

Adaptive evolution of hybrid bacteria by horizontal gene transfer

This study shows that horizontal gene transfer rapidly generates adaptive hybrid bacteria with genomic and functional changes in a parallel evolution experiment.