S. J. Leedham

GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche via stromal remodelling

Pathological epithelial GREM1 expression induces therapeutically reversible ectopic stem cell niches through stromal remodelling.

Extended correlation functions for spatial analysis of multiplex imaging data

This paper introduces three extensions to the cross-pair correlation function for spatial analysis of multiplex imaging data, demonstrating their application on synthetic and biological datasets.

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

The paper examines stem cell population dynamics in colorectal tumors, showing that CBC-RSC admixture correlates with mutations and microenvironmental changes, and is linked to chemoresistance.

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

This study shows that β-catenin signaling in colon cancer cells reduces BTNL expression, impairing γδ T cell immunosurveillance and promoting tumor progression.

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

This study shows that Grem1 antagonizes BMP signaling to regulate epithelial cell fate during intestinal regeneration.

Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning

This paper develops imCMS, a deep learning method to classify colorectal cancer subtypes from histological images, showing improved accuracy over bioinformatic methods.