Repeated evolution of bedaquiline resistance in Mycobacterium tuberculosis is driven by truncation of mmpR5
L. W. Roberts, K. M. Malone, M. Hunt, L. Joseph, P. Wintringer, J. Knaggs, D. Crook, M. R. Farhat, Z. Iqbal, S. V. Omar
The paper identifies truncation of mmpR5 as a driver of bedaquiline resistance in Mycobacterium tuberculosis through analysis of clinical isolates and MIC measurements.
bioRxiv · Dec 8, 2022 · PreprintMicrobiology