Author

D. C. Lye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:flow cytometry· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

B. E. Young· 3 shared G. Carissimo· 3 shared L. Renia· 3 shared N. K.-W. Yeo· 3 shared R. S.-L. Chee· 3 shared S. Kalimuddin· 3 shared S. N. Amrun· 3 shared Y.-S. Leo· 3 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

B. E. Young

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

J. Lim, G. Carissimo, Y.-H. Chan, S.-W. Fong, W. W. Lee, S.-Y. Tan, D. C. Lye, B. E. Young, L. Renia, L. Fong-Poh NG, O. Rotzschke, K. J. Puan, L. W. Wang, K. W. W. Teng, C. Y. Loh, , B. Lee

The paper identifies immune signatures associated with COVID-19 severity and temporality, revealing distinct patterns and providing tools for data analysis.

bioRxiv · Feb 10, 2021 · PreprintImmunology

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

N. Le Bert, H. E. Clapham, A. T. Tan, W. N. Chia, C. Y. Tham, J. M. Lim, K. Kunasegaran, L. Tan, C.-A. Dutertre, N. Shankar, J. M. Lim, L. J. Sun, M. Zahari, Z. M. Tun, V. Kumar, , C. C. Tam

This study compares T cell responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that asymptomatic individuals have a robust and functional immune response with balanced cytokine production.

bioRxiv · Nov 25, 2020Immunology

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19

G. Carissimo, W. Xu, I. Kwok, M. Y. Abdad, Y. H. Chan, S. W. Fong, K. J. Puan, C. Y. P. Lee, N. K.-W. Yeo, S. N. Amrun, R. S.-L. Chee, W. How, S. Chan, E. B. Fan, A. Andiappan, , L. F. Ng

The paper identifies an immature neutrophil-to-VD2 T-cell ratio as a prognostic marker for severe COVID-19 using flow cytometry data.

bioRxiv · Jun 11, 2020Immunology

Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein

C. M. Poh, G. Carissimo, W. Bei, S. N. Amrun, C. Y.-P. Lee, R. S.-L. Chee, N. K.-W. Yeo, W.-H. Lee, Y.-S. Leo, M. I.-C. Chen, S.-Y. Tan, L. Y. A. Chai, S. Kalimuddin, S.-Y. Thien, B. E. Young, , L. F. Ng

The paper identifies two immunodominant linear epitopes on the SARS-CoV-2 spike protein that are targets of potent neutralizing antibodies in convalescent patient sera.

bioRxiv · Mar 30, 2020Immunology

Dominance of ST131 Escherichia coli carrying blaCTX-M in patients with bloodstream infections caused by cephalosporin-resistant strains in Australia, New Zealand and Singapore: whole genome analysis of isolates from a randomised trial

P. Harris, N. Ben Zakour, L. W. Roberts, A. M. Wailan, H. M. Zowawi, P. A. Tambyah, D. C. Lye, R. Jureen, T. H. Lee, E. Izharuddin, M. Yin, D. Looke, N. Runnegar, B. Rogers, H. Bhally, , D. L. Paterson

The paper characterizes multidrug-resistant Escherichia coli from bloodstream infections in Australia, New Zealand, and Singapore, finding ST131 dominates with blaCTX-M ESBLs, particularly blaCTX-M-15.

bioRxiv · Aug 29, 2017Microbiology