Z. Iqbal

Very high frequencies of Familial Breast Cancer, low BRCA1/2 mutations and high Luminal molecular subtypes in Eastern Saudi Arabia necessitate the hunt for novel breast cancer hub genes

Repeated evolution of bedaquiline resistance in Mycobacterium tuberculosis is driven by truncation of mmpR5

The paper identifies truncation of mmpR5 as a driver of bedaquiline resistance in Mycobacterium tuberculosis through analysis of clinical isolates and MIC measurements.

Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination and Drug Susceptibility Prediction

This study evaluates direct-from-sputum whole-genome sequencing for tuberculosis diagnosis, lineage determination, and drug susceptibility prediction using different sequencing technologies.

Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach

This study identifies 230 genomic variants associated with resistance to bedaquiline and clofazimine in tuberculosis using experimental evolution, genome sequencing, and structural modeling.

Exploring bacterial diversity via a curated and searchable snapshot of archived DNA sequences

The paper curates and analyzes 661,405 bacterial genomes from ENA, revealing biases in species representation and highlighting common human pathogens as overrepresented.

Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei

The paper develops a genomic framework and genotyping scheme for Shigella sonnei to identify resistance determinants from WGS data, revealing common genotypes linked to antimicrobial resistance and global spread.

A novel multi SNP based method for the identification of subspecies and associated lineages and sub-lineages of the Mycobacterium tuberculosis complex by whole genome sequencing

This paper introduces SNP-IT, a method using whole genome sequencing to identify subspecies and lineages of Mycobacterium tuberculosis complex, revealing high prevalence of M. orygis in UK clinical isolates.

The global distribution and spread of the mobilized colistin resistance gene mcr-1

The paper analyzes the global spread of the mcr-1 gene by sequencing isolates and phylogenetic analysis, finding all mcr-1 elements originated from a single mobilization event in the mid-2000s.

Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples.

This paper develops a low-cost WGS method for TB diagnosis and surveillance using direct respiratory samples, achieving rapid results with high concordance with reference labs.