Author

L. Zubcevic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Organism:rat· 1

Frequent Co-Authors

L. G. Schrag· 2 shared S.-Y. Lee· 2 shared A. Jara-Oseguera· 1 shared A. L. Hsu· 1 shared A. Song· 1 shared A. Zolkiewska· 1 shared G. C. Lander· 1 shared I. Thevarajan· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

L. G. Schrag

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4 papers

Recent·Most cited

Structural dynamics at cytosolic inter-protomer interfaces control gating of a mammalian TRPM5 channel

S. Karuppan, L. G. Schrag, A. Jara-Oseguera, L. Zubcevic

This study investigates how cytosolic inter-protomer interfaces in TRPM5 channels control gating through Ca2+-induced conformational changes.

bioRxiv · Aug 26, 2023 · PreprintBiophysics

Human Mitochondrial AAA+ ATPase SKD3/CLPB forms Nucleotide-Stabilized Dodecamers

Z. Spaulding, I. Thevarajan, L. G. Schrag, L. Zubcevic, A. Zolkiewska, M. Zolkiewski

This study characterizes the oligomeric structure of SKD3/CLPB, showing it forms nucleotide-stabilized dodecamers with a unique double-hexamer architecture.

bioRxiv · Dec 16, 2021Biochemistry

Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

L. Zubcevic, A. L. Hsu, M. J. Borgnia, S.-Y. Lee

This study uses cryo-EM to show that RTx induces two-fold symmetric conformations of TRPV2, with greater symmetry in nanodiscs than in amphipol.

bioRxiv · Feb 8, 2019Biophysics

Conformational ensemble of the human TRPV3 ion channel

L. Zubcevic, M. A. Herzik, M. Wu, W. F. Borschel, M. Hirschi, A. Song, G. C. Lander, S.-Y. Lee

The paper presents cryo-EM structures of human TRPV3 in different states to elucidate its sensitization and gating mechanisms.

bioRxiv · Aug 20, 2018Biochemistry