Author

M. Hirschi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

G. C. Lander· 2 shared A. E. Stewart· 1 shared A. M. Gilbert· 1 shared A. Nagata· 1 shared A. R. Nager· 1 shared A. Song· 1 shared B. Basanta· 1 shared B. F. Cravatt· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

G. C. Lander

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Author profile →

3 papers

Recent·Most cited

Expanding the ligandable proteome by paralog hopping with covalent probes

Y. Zhang, Z. Liu, M. Hirschi, O. Brodsky, E. Johnson, S. J. Won, A. Nagata, M. D. Petroski, J. D. Majmudar, S. Niessen, T. VanArsdale, A. M. Gilbert, M. M. Hayward, A. E. Stewart, A. R. Nager, , B. F. Cravatt

The paper uses covalent probes and paralog hopping to identify ligandable pockets in proteins lacking cysteines, demonstrating a method to expand the ligandable proteome.

bioRxiv · Jan 18, 2024 · PreprintBiochemistry

A case for glycerol as an acceptable additive to cryoEM samples

B. Basanta, M. Hirschi, D. A. Grotjahn, G. C. Lander

This study shows glycerol can be used as a cryoEM sample additive without compromising high-resolution structure determination, using mouse apoferritin and rabbit muscle aldolase as examples.

bioRxiv · Sep 10, 2021Biophysics

Conformational ensemble of the human TRPV3 ion channel

L. Zubcevic, M. A. Herzik, M. Wu, W. F. Borschel, M. Hirschi, A. Song, G. C. Lander, S.-Y. Lee

The paper presents cryo-EM structures of human TRPV3 in different states to elucidate its sensitization and gating mechanisms.

bioRxiv · Aug 20, 2018Biochemistry