Author

L.-C. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. R. Yates· 3 shared L. Gerace· 3 shared S. Baboo· 3 shared X. Zhang· 3 shared E. Loose· 2 shared J. A. Nguyen· 2 shared S. Martinez-Bartolome· 2 shared A. Lawless· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

J. R. Yates

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Author profile →

4 papers

Recent·Most cited

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

O.-Y. Revach, A. M. Cicerchia, O. Shorer, B. Petrova, S. Anderson, J. Park, L. Chen, A. Mehta, S. J. Wright, N. McNamee, A. Tal-Mason, G. Cattaneo, P. Tiwari, H. Xie, J. M. Sweere, , K. Yizhak

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

bioRxiv · Feb 12, 2024 · PreprintCancer Biology

Comparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope

L.-C. Cheng, X. Zhang, S. Baboo, J. A. Nguyen, S. Martinez-Bartolome, E. Loose, J. Diedrich, J. R. Yates, L. Gerace

The paper identifies novel transmembrane proteins enriched at the nuclear envelope using proteomics and validates their localization and function.

bioRxiv · Feb 13, 2023Cell Biology

Shared and distinctive neighborhoods of emerin and LBR revealed by proximity labeling and quantitative proteomics

L.-C. Cheng, X. Zhang, K. Abhinav, J. A. Nguyen, S. Baboo, S. Martinez-Bartolomé, T. C. Branon, A. Y. Ting, E. Loose, J. R. Yates, L. Gerace

The paper uses proximity labeling and proteomics to identify proteins interacting with emerin and LBR at the inner nuclear membrane, revealing shared and distinct partners.

bioRxiv · May 11, 2022 · PreprintCell Biology

Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells

L.-C. Cheng, S. Baboo, C. Lindsay, L. E. Brusman, S. Martinez-Bartolome, O. Tapia, X. Zhang, J. R. Yates, L. Gerace

The paper identifies five new transmembrane proteins enriched at the nuclear envelope in mesenchymal cells using proteomics and immunofluorescence validation.

bioRxiv · Dec 3, 2018Cell Biology