P. Tiwari

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

A glucanotransferase that uses two sub-sites and four catalytic aspartates/glutamates to disproportionate oligosaccharides ranging in length from maltotriose to starch

This paper demonstrates that PfuAmyGT is an exo-amylase-cum-glucanotransferase capable of transferring glucose and disproportionating oligosaccharides using separate sub-sites for donor and acceptor binding.

Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks

This paper shows that EP300 deficiency causes chronic replication stress and genomic instability in ATLL cells by impairing fork protection and leading to DNA damage and mitotic defects.

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting heads motif and super-relaxed state of myosin

This study shows that the E525K mutation in human beta-cardiac myosin stabilizes the super-relaxed state and interacting-heads motif, potentially reducing muscle force and power.

Limited inhibition of multiple nodes in a driver network blocks metastasis

The paper shows that limited inhibition of multiple core pathways in a driver network effectively blocks metastasis in mouse breast cancer models.

Metabolically activated macrophages in mammary adipose tissue link obesity to triple-negative breast cancer

This study shows that obesity-induced metabolically activated macrophages in mammary adipose tissue promote triple-negative breast cancer stemness and tumorigenesis through GP130 signaling.