Author

L.-Y. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:bacteria (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

N. Mukkayyan· 2 shared N. Satishkumar· 2 shared S. S. Chatterjee· 2 shared B. Vogel· 1 shared H. F. Chambers· 1 shared L. B. Marques· 1 shared L. Huang· 1 shared M. G. Pinho· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

N. Mukkayyan

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Author profile →

3 papers

Recent·Most cited

Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus

L.-Y. Lai, N. Satishkumar, S. Cardozo, V. Hemmadi, L. B. Marques, L. Huang, S. R. Filipe, M. G. Pinho, H. F. Chambers, S. S. Chatterjee

This study identifies that mutations in PBP4 and GdpP synergistically confer high-level, broad-spectrum β-lactam resistance in mecA-deficient Staphylococcus aureus strains.

bioRxiv · Oct 26, 2023 · PreprintMicrobiology

A non-classical mechanism of β-lactam resistance in Methicillin-Resistant Staphylococcus aureus (MRSA) and its effect on virulence

N. Satishkumar, L.-Y. Lai, N. Mukkayyan, B. Vogel, S. Chatterjee

This study shows that PBP4 overexpression can enhance β-lactam resistance in MRSA and reduce virulence in a C. elegans model.

bioRxiv · Jun 17, 2022 · PreprintMicrobiology

In-vivo detection of cyclic-di-AMP in Staphylococcus aureus

N. Mukkayyan, R. Poon, P. Sander, L.-Y. Lai, Z. Zubair-Nizami, M. Hammond, S. S. Chatterjee

This study develops a biosensor for in-vivo detection of cyclic-di-AMP in Staphylococcus aureus, showing its ability to detect a wide concentration range in both laboratory and clinical strains.

bioRxiv · May 16, 2022Microbiology