Author

H. F. Chambers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Bayer· 2 shared L. Huang· 2 shared N. Satishkumar· 2 shared S. C. Ersoy· 2 shared S. S. Chatterjee· 2 shared Y. Q. Xiong· 2 shared A. Chatterjee· 1 shared A. M. Bienvenida· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

A. Bayer

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Author profile →

4 papers

Recent·Most cited

Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus

L.-Y. Lai, N. Satishkumar, S. Cardozo, V. Hemmadi, L. B. Marques, L. Huang, S. R. Filipe, M. G. Pinho, H. F. Chambers, S. S. Chatterjee

This study identifies that mutations in PBP4 and GdpP synergistically confer high-level, broad-spectrum β-lactam resistance in mecA-deficient Staphylococcus aureus strains.

bioRxiv · Oct 26, 2023 · PreprintMicrobiology

Loss of GdpP function in Staphylococcus aureus leads to β-lactam tolerance and enhanced evolution of β-lactam resistance

R. Poon, L. Basuino, N. Satishkumar, A. Chatterjee, N. Mukkayyan, E. Buggeln, L. Huang, V. Nair, M. A. Argudin, S. K. Datta, H. F. Chambers, S. S. Chatterjee

This study shows that loss of GdpP function in Staphylococcus aureus increases β-lactam tolerance and facilitates the evolution of β-lactam resistance.

bioRxiv · Jul 2, 2021Microbiology

Ability of Bicarbonate Supplementation to Sensitize Selected Methicillin-Resistant Staphylococcus aureus (MRSA) Strains to β-Lactam Antibiotics in an Ex Vivo Simulated Endocardial Vegetation Model

W. E. Rose, A. M. Bienvenida, Y. Q. Xiong, H. F. Chambers, A. Bayer, S. C. Ersoy

This study shows that bicarbonate supplementation increases β-lactam susceptibility in certain MRSA strains in an ex vivo endocarditis model, but not in others.

bioRxiv · Oct 16, 2019Microbiology

Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics

S. C. Ersoy, W. Abdelhady, L. Li, H. F. Chambers, Y. Q. Xiong, A. Bayer

This study shows that sodium bicarbonate can make certain MRSA strains susceptible to beta-lactam antibiotics by reducing expression of resistance genes.

bioRxiv · Mar 9, 2019Microbiology