Discriminative SKP2 interactions with CDK-cyclin complexes support a cyclin A-specific role in p27KIP1 degradation
M. Salamina, B. C. Montefiore, M. Liu, D. J. Wood, R. Heath, J. R. Ault, L.-Z. Wang, S. Korolchuk, A. Basle, M. W. Pastok, J. Reeks, N. J. Tatum, F. Sobott, S. T. Arold, M. Pagano, , J. A. Endicott
The paper identifies a cyclin A-specific interaction between SKP2 and CDK2-cyclin A complexes that promotes p27KIP1 degradation, distinguishing cyclin A from other G1 cyclins.
bioRxiv · Oct 8, 2020Biochemistry