Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies
Julia Lederhofer, Andrew J. Borst, Lam Nguyen, Rebecca A. Gillespie, Connor Williams, Emma L. Walker, Julie E. Raab, Christina Yap, Daniel Ellis, Adrian Creanga, Hyon‐Xhi Tan, Thi H. T. Do, Michelle Ravichandran, Adrian B. McDermott, Valerie Le Sage, , Masaru Kanekiyo
This study identifies human antibodies that broadly inhibit influenza neuraminidase by mimicking its substrate through structural convergence and water-mediated interactions.
Nature Communications · Aug 1, 2025Peer-reviewedImmunology