Adam K. Wheatley

Live attenuated YFV-17D vaccine induces robust B and T cell immunity in vaccine-draining lymph nodes

This study examines immune dynamics in lymph nodes after YFV-17D vaccination, identifying robust B and T cell responses and a conserved germinal center program across different vaccines.

Immunogen selection and prior immunity shape antibody breadth following immunisation with avian H5 hemagglutinin

This study shows that vaccine strain selection and prior immunity influence antibody breadth against avian H5 hemagglutinin in mice.

Epistasis facilitates the long-term antigenic evolution of the influenza B virus hemagglutinin

The paper analyzes the antigenic evolution of influenza B virus hemagglutinin over 8 decades, identifying epistatic networks that balance antigenic novelty with viral fitness.

Pre-existing systemic and nasal antibodies against avian H5 influenza A viruses vary according to childhood imprinting

The paper examines pre-existing antibodies against avian H5 influenza A viruses in individuals born between 1928-1999, showing variations based on childhood exposure and birth year.

Novel monoclonal antibodies targeting distinct sites on placental binding P. falciparum antigen VAR2CSA synergistically enhance parasite phagocytosis

The paper identifies VAR2CSA-specific monoclonal antibodies that synergistically enhance phagocytosis of malaria-infected red blood cells when combined, but none inhibit CSA binding.

Defining influenza-specific B cells in vaccine responders, non-responders and influenza breakthrough infections

This study identifies atypical B cell markers associated with influenza vaccine non-responsiveness and severe infection using single-cell transcriptomics.

A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses

A chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and HKU-1 scaffold domains elicits potent neutralising antibodies and CD4 T cell help in mice and macaques.

Impact of serum versus anticoagulant-containing plasma on influenza virusneuraminidase-based serological assays

This study compares NA-specific antibody titres in serum and plasma using ELLA and ELISA, finding discrepancies and recommending serum for standardized assays.

Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies

This study identifies human antibodies that broadly inhibit influenza neuraminidase by mimicking its substrate through structural convergence and water-mediated interactions.

De novo administration of antiviral monoclonal antibodies against SARS-CoV-2 or influenza using mRNA lipid nanoparticles

This study compares traditional mAb infusion with mRNA/LNP-based de novo mAb expression in mice, finding high serum concentrations but compromised protective capacity due to anti-drug antibodies.

Immunodominance is a poor predictor of vaccine-induced T follicular helper cell quality

The paper investigates the relationship between CD4 T cell epitope immunodominance and vaccine-induced T follicular helper cell quality, finding that immunodominance is not predictive of helper quality.

Memory T and B cells with recognition of avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines

The paper quantifies pre-existing human B cell responses to avian influenza H5 and H7 hemagglutinins and shows limited boosting by seasonal vaccines.

Deconvoluting TCR-dependent & -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay

The paper shows that AIM assays overestimate Ag-specific CD4+ T cells due to TCR-independent activation and introduces a modified assay using CXCR4-CD137+ cells for accurate characterization.

Triton-X 100-treated virus-based ELLA demonstrates discordant antigenic evolution of influenza B virus haemagglutinin and neuraminidase

This paper demonstrates that Triton-X 100-treated virus-based ELLA overcomes HA interference in IBV, revealing discordant antigenic evolution between HA and NA.

Survey of activation-induced genome architecture reveals a novel enhancer of Myc

The paper identifies a novel Myc enhancer activated in B cells shortly after activation but finds it is not essential for Myc expression or cell proliferation.