Virginie Pétrilli

This study shows that postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC-dependent signaling pathway, which is sexually dimorphic and disrupted in obesity.

This study shows that linear ubiquitination, mediated by LUBAC, is essential for the execution phase of NLRP3-mediated pyroptosis, independent of priming.

This study identifies CRY-NLRP3 complexes as a circadian checkpoint that modulates inflammasome activation and drug response, showing time-of-day effects on inflammation and drug efficacy.

This study shows that pore-size dynamics in pyroptosis control cell swelling through GSDMD and Ninj1, with distinct permeability regimes affecting ion selectivity and water filtration.

This study shows that L-asparaginase treatment induces metabolic plasticity in B-cell lymphomas, making them vulnerable to PARP1/2 inhibitor Olaparib, with potential broader therapeutic applications.

This study shows NLRP3 promotes homologous recombination by interacting with REV7, enhancing DNA repair and affecting PARP inhibitor sensitivity.

This study identifies neutrophils as the earliest immune cells involved in surveilling preneoplastic breast cancer cells through UPR activation and immunogenic signaling.

This study shows membrane tension drives NINJ1 filament opening, causing cell lysis, and explains why NINJ2 fails to form lesions.