Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro
Qinghe Zeng, Landon Flemming, Yuanzhou Chen, Thomas Mazumder, Heinz Hammerlindl, Greg M. Allen, Ricardo Almeida, Jasper Z. Williams, Rogelio Antonio Hernández-López, Justin Eyquem, Chun Ye, Wendell A. Lim, Qizhi Tang, Tejal Ashwin Desai, Xiao Huang
This study uses programmable microparticles to enhance CAR-T cell expansion beyond physiological limits by rewiring signaling pathways.
bioRxiv · Jul 17, 2025 · PreprintImmunology