Thomas Mazumder

This paper introduces SCITO-Perturb-seq, a CRISPRa platform that maps surface protein regulation in CD4 T cells, finding 16% of activated genes alter surface protein expression.

This study identifies allergen-reactive Th2 cells in human airways using high-dimensional profiling and shows their systemic expansion following allergen challenge.

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

This study uses programmable microparticles to enhance CAR-T cell expansion beyond physiological limits by rewiring signaling pathways.

The paper uses allelic inclusion data to train models that identify antibody sequence constraints, finding stronger correlations with antibody properties than existing methods.