Greg M. Allen

This paper identifies methods to achieve ultra-large DNA integrations (>10 kb) in human cells with high efficiency using optimized templates and delivery strategies.

This paper introduces Hybrid Receptors (Hybrid-Rs) to improve T cell therapy safety and programmability by combining CAR and SNIPR features for controlled gene regulation and reduced toxicity.

This paper performs in vivo CRISPR screens in human T cells to identify genetic modifiers of T cell function in solid tumors, finding P2RY8-G13 and GNAS as key regulators.

This study uses programmable microparticles to enhance CAR-T cell expansion beyond physiological limits by rewiring signaling pathways.

This paper engineers T cells with synthetic receptors that activate only in the lung, demonstrating RAGE as a lung-specific target for targeted therapies.