Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19
Candice N. Baker, Debra K. Duso, Naga Rama Kothapalli, Tricia Hart, Sean Casey, Tres S. Cookenham, Larry W. Kummer, Janine Hvizdos, Kathleen G. Lanzer, Purva Vats, Priya Shanbhag, Isaac Bell, Mike Tighe, Kelsey L. Travis, Frank M. Szaba, , Nadia A Rosenthal
The paper characterizes the CAST/EiJ mouse strain as a model for severe COVID-19 by showing it develops high viral burdens, severe lung pathology, and cytokine dysregulation leading to mortality.
Scientific Reports · Oct 24, 2024Peer-reviewedImmunology