Mouse Models Uniformly Featuring Human-like Lesions Harboring Drug-tolerant Mycobacterium tuberculosis
Gaëlle Guiewi Makafe, Timothy C. Low-Beer, Kelsey L. Travis, Laura Cole, Derek T. Bernacki, Debra K. Duso, Matthew Cole, Larry Kummer, Alan Roberts, Tricia Hart, Kathryn Roemer, William W. Reiley, Mike Tighe, Brian C. Weinrick
The paper develops two mouse models that consistently produce human-like hypoxic necrotic lesions with drug-tolerant Mycobacterium tuberculosis.
bioRxiv · Oct 17, 2025 · PreprintMicrobiology