BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis
Júlia Bonjoch, Paloma Solá, Óscar Reina, Thomas Mortimer, Yekaterina A. Miroshnikova, Sara A. Wickström, Camille Stephan‐Otto Attolini, Laura Álvarez, Salvador Aznar Benitah, Guiomar Solanas
This study identifies a BMAL1-YAP transcriptional complex that hijacks enhancers in aged epidermis to promote inflammation by rewiring chromatin dynamics and co-regulating inflammation-related genes with NF-KB.
bioRxiv · Apr 22, 2025 · PreprintMolecular Biology