Alexandre David

This study shows E4F1 regulates melanogenesis in mice by controlling protein translation and MITF expression through the ISR pathway.

SPEAR combines laser microdissection and LC-MS/MS to enable spatial epitranscriptomic profiling of FFPE tissue, revealing RNA modification changes in glioma progression.

The paper benchmarks cross-platform RNA modification quantification using LC-MS/MS and finds that harmonized workflows and SILIS normalization improve reproducibility across different instrument types.

This study identifies miR-4745 as a regulator of cancer stem cell traits in colorectal cancer, showing it inhibits CSC self-renewal and chemoresistance by targeting KLC2.

This study shows that sex hormones influence corneal graft rejection risk by modulating tear composition, epithelial dynamics, and sensory function, with androgen treatment reversing these sex-linked differences.

This study shows that the K-D-K-E motif in RABV L protein's methyltransferase domain is crucial for immune evasion by altering viral and host RNA methylation, increasing sensitivity to interferon, and reducing pathogenicity.

This study investigates corneal wound healing using multi-omics analyses, identifying molecular factors and epithelial plasticity mechanisms critical for tissue regeneration.

The paper shows 5-FU induces translational reprogramming in colorectal cancer cells, enhancing drug tolerance through pro-tumoral gene expression and IL-8 overexpression.

RNA-Ribo Explorer provides an interactive tool for analyzing and visualizing Ribo-seq data to explore translation dynamics and detect changes in RNA translation across conditions.