Jérôme Vialaret

SPEAR combines laser microdissection and LC-MS/MS to enable spatial epitranscriptomic profiling of FFPE tissue, revealing RNA modification changes in glioma progression.

This study identifies conserved and species-specific molecular pathways in tear film during corneal wound healing in humans and mice.

This study shows that sex hormones influence corneal graft rejection risk by modulating tear composition, epithelial dynamics, and sensory function, with androgen treatment reversing these sex-linked differences.

This study uses proteomic analysis to track tear fluid changes after PRK, identifying key molecular events in corneal repair and potential biomarkers for healing.

The paper models RLBP1-related retinal diseases using iPSC-derived RPE and validates a gene replacement strategy, identifying a novel CRALBP isoform with functional significance.

This study shows that OPA1 mutation causes corneal innervation issues, including reduced sensitivity and impaired regeneration, despite normal epithelial function.

This paper introduces a Bayesian modeling approach to capture population protein dynamics using cohort data, showing its ability to handle inter-individual variability.

This study develops a 3-compartment model to simultaneously analyze protein dynamics in blood plasma and cerebrospinal fluid, including a hidden CNS compartment, and applies it to 69 proteins from a single individual.

A single short reprogramming early in life rejuvenates cell physiology, improves body composition, tissue fitness and increases lifespan in elderly.

The paper introduces a proteomics framework to map protein turnover in human cerebrospinal fluid, identifying turnover rates for nearly 200 proteins and revealing relationships between turnover and protein origin.