IL-12R signaling promotes type 1 regulatory T cell specialization by sustaining T-bet
Anna Estrada Brull, Ylva M. Carlen, Laura Revert Rubio, Pascale Zwicky, Sarah Mundt, Burkhard Becher, Nicole Joller
This study shows IL-12R signaling sustains T-bet in Treg cells, promoting type 1 specialization and enhancing suppressive function against Th1 responses.
bioRxiv · Jan 11, 2026 · PreprintImmunology