Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
Alessio Vittorio Colombo, Lina Dinkel, Stephan A. Müller, Laura Sebastián Monasor, Martina Schifferer, Ludovico Cantuti‐Castelvetri, Jasmin König, Lea Vidatic, Tatiana Brémovà-Ertl, Andrew P. Lieberman, Silva Katusic Hecimovic, Mikael Simons, Stefan F. Lichtenthaler, Michael Leo Strupp, Susanne A. Schneider, Sabina Tahirović
This study shows that loss of NPC1 in microglia increases phagocytic uptake and impairs lipid trafficking, leading to myelin accumulation and potential therapeutic implications.
Nature Communications · Feb 24, 2021Peer-reviewedNeuroscience