Andrew P. Lieberman

The paper determines the structure of tau filaments in Alzheimer's disease patients with co-morbid LATE-NC using cryo-electron microscopy, revealing a CTE-type tau fold in addition to the Alzheimer's fold.

The paper identifies two SIRT5 variants in mitochondrial disease patients that reduce protein stability and activity but not neuropathology, using biochemical and mouse model analyses.

This study shows that loss of NPC1 in microglia increases phagocytic uptake and impairs lipid trafficking, leading to myelin accumulation and potential therapeutic implications.

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.