Author

Leah M. Hirsch

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

A. MuelleriD· 1 shared Adam G. MaynardiD· 1 shared Alan Y. L. WongiD· 1 shared Andrew J. Culhane· 1 shared Boryana PetrovaiD· 1 shared Hojun LiiD· 1 shared Jeannette R. BrookiD· 1 shared Mark D. FlemingiD· 1 shared

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2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

A. MuellerORCID

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1 paper

Recent·Most cited

Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis

Adam G. Maynard, Nancy K. Pohl, A. Mueller, Boryana Petrova, Alan Y. L. Wong, Peng Wang, Andrew J. Culhane, Jeannette R. Brook, Leah M. Hirsch, Ngoc Hoang, Orville O. Kirkland, Tatum W. Braun, Sarah Ducamp, Mark D. Fleming, Hojun Li, Naama Kanarek

This study shows folate depletion induces erythroid differentiation by disrupting purine synthesis, with effects mimicked by SHIN1 inhibition and rescued by purine precursor supplementation.

Science Advances · Jan 31, 2024Peer-reviewedMolecular Biology