Molecular BiologyScience AdvancesPeer-reviewed
Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis
Adam G. Maynard, Nancy K. Pohl, A. Mueller…·Naama Kanarek
This study shows folate depletion induces erythroid differentiation by disrupting purine synthesis, with effects mimicked by SHIN1 inhibition and rescued by purine precursor supplementation.