Alan Y. L. Wong

This study shows folate deprivation impairs CD8+ T cell function by disrupting cell surface glycosylation, and increasing folate uptake enhances T cell anti-tumor activity.

This study optimizes LC-MS detection of retinoids in cerebrospinal fluid, showing that tailored parameters are needed for reliable identification in low-abundance biofluids.

This paper shows that adrenergic signaling coordinates systemic and local stem cell activation after amputation in axolotls, enhancing regeneration.

This study identifies RXR signaling as a mediator of lipid metabolism in leptomeningeal metastatic cancer cells, revealing a potential therapeutic target.

This paper introduces Pyxis, a machine learning tool for absolute metabolite quantification in metabolomics, demonstrating its scalability and efficiency compared to traditional methods.

This study shows folate depletion induces erythroid differentiation by disrupting purine synthesis, with effects mimicked by SHIN1 inhibition and rescued by purine precursor supplementation.