Author

Nancy K. Pohl

Boston Children's HospitalORCID 0000-0002-9173-3247Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. MuelleriD· 1 shared Adam G. MaynardiD· 1 shared Alan Y. L. WongiD· 1 shared Andrew J. Culhane· 1 shared Boryana PetrovaiD· 1 shared Eric Lieberman GreeriD· 1 shared Gautam Chandra SarkariD· 1 shared Hojun LiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

A. MuellerORCID

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2 papers

Recent·Most cited

The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life

M. Hafiz Rothi, Gautam Chandra Sarkar, Joseph Al Haddad, Wayne Mitchell, Kejun Ying, Nancy K. Pohl, Roberto G. Sotomayor-Mena, Julia Natale, Scarlett Dellacona, Vadim N. Gladyshev, Eric Lieberman Greer

This study identifies DIMT-1 as a regulator of C. elegans lifespan and stress resistance through its role in rRNA methylation and germline function.

Nature Communications · Jul 28, 2025Peer-reviewedGenetics

Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis

Adam G. Maynard, Nancy K. Pohl, A. Mueller, Boryana Petrova, Alan Y. L. Wong, Peng Wang, Andrew J. Culhane, Jeannette R. Brook, Leah M. Hirsch, Ngoc Hoang, Orville O. Kirkland, Tatum W. Braun, Sarah Ducamp, Mark D. Fleming, Hojun Li, Naama Kanarek

This study shows folate depletion induces erythroid differentiation by disrupting purine synthesis, with effects mimicked by SHIN1 inhibition and rescued by purine precursor supplementation.

Science Advances · Jan 31, 2024Peer-reviewedMolecular Biology