FXR-mediated recruitment of PPP1CB suppresses SMAD2/3 phosphorylation to mitigate pulmonary fibrosis
Wenqi Li, Qiong Wu, Yongzhi Lu, Xiaoqin Li, Lei Miao, Xia Y, Xianjie Qiu, Miru Tang, Z Y Li, Yang Peng, Wenxiang Hu, Wei Kevin Zhang, Jie Zheng, Cong Ma, Jinsai Shang
This study identifies FXR as a suppressor of pulmonary fibrosis by interacting with PPP1CB to reduce SMAD2/3 phosphorylation, showing therapeutic potential with TERN101.
bioRxiv · Jul 24, 2026 · PreprintCell Biology