David Charles Hess

A Shifting Immune Landscape: ILC Redistribution and Neutrophil Polarization in Vascular Cognitive Impairment and Dementia (VCID)

This study investigates how vascular dysfunction in VCID affects innate immune cells, finding compartment-specific ILC redistribution and pro-inflammatory neutrophil polarization in the brain.

Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control

This study investigates how cannabidiol affects IDO and cGAS pathways in Alzheimer's disease using a mouse model, finding reduced inflammation and cytokine levels.

Optimization of Seizure Prevention by Cannabidiol (CBD)

This study evaluates the effectiveness of different CBD formulations and delivery routes in reducing seizure severity in a mouse model of epilepsy, finding inhaled broad-spectrum CBD to be most effective.

Cannabidiol reverses fentanyl-induced addiction and modulates neuroinflammation

This study investigates whether inhaled cannabidiol (CBD) can reverse fentanyl addiction and modulate neuroinflammation in a mouse model.

AIM2 Inflammasome Mediates Hallmark Neuropathological Alterations and Cognitive Impairment in a Mouse Model of Vascular Dementia

This study shows that AIM2 inflammasome activation contributes to brain injury and cognitive impairment in a mouse model of vascular dementia.