Author

Leire Goicoechea Barrenechea

The Royal Free Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Antonella SpinazzolaiD· 2 shared Alan David SalamaiD· 1 shared Amaia López de ArbinaiD· 1 shared Claudia MauriiD· 1 shared David M. LoweiD· 1 shared Diego Pérez‐RodrígueziD· 1 shared Guillem MontamatiD· 1 shared Hannah F. BradfordiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Antonella SpinazzolaORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 4, 2026

Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction

Seungtae Lee, Mikel Muñoz‐Oreja, Marina Villar-Fernandez…·Ian James Holt

This study shows that elevated cholesterol in APOE4 astrocytes causes mitochondrial cristae collapse and ATP synthase dysfunction, linking cholesterol imbalance to mitochondrial disease.

DOI 10.64898/2026.08.04.742391

mouseATAC-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 6, 2026

Neutrophils impair B cell differentiation via mitochondrial and lipid metabolism in lupus.

Hannah F. Bradford, Guillem Montamat, Leire Goicoechea Barrenechea…·Marilina Antonelou

This study shows neutrophil-derived mitochondrial DNA impairs B cell differentiation in lupus nephritis through oxidative stress and lipid metabolism disruption.

DOI 10.64898/2026.02.03.703615

humanbulk RNA-seq

𝕏 PostBluesky