Author

Mikel Muñoz‐Oreja

Biogipuzkoa Health Research InstituteORCID 0000-0002-9239-1971Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Antonella SpinazzolaiD· 2 shared Ian James HoltiD· 2 shared Agnieszka Rybak‐WolfiD· 1 shared Alessandro PrigioneiD· 1 shared Amaia López de ArbinaiD· 1 shared Andrea Rossi· 1 shared Andrea ZalianiiD· 1 shared Annette Seibt· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

Antonella SpinazzolaORCID

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2 papers

Recent·Most cited

Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction

Seungtae Lee, Mikel Muñoz‐Oreja, Marina Villar-Fernandez, Leire Goicoechea Barrenechea, Uxoa Fernández‐Pelayo, Diego Pérez‐Rodríguez, Matthew E. Gegg, Amaia López de Arbina, Antonella Spinazzola, Ian James Holt

This study shows that elevated cholesterol in APOE4 astrocytes causes mitochondrial cristae collapse and ATP synthase dysfunction, linking cholesterol imbalance to mitochondrial disease.

bioRxiv · Aug 4, 2026 · PreprintCell Biology

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

Carmen Menacho, Satoshi Okawa, Iris Álvarez‐Merz, Annika Wittich, Mikel Muñoz‐Oreja, Paweł Lisowski, Tancredi Massimo Pentimalli, Agnieszka Rybak‐Wolf, Gizem Inak, Shiri Zakin, Mathuravani A. Thevandavakkam, Laura Petersilie, Andrea Zaliani, Barbara Mlody, Annette Seibt, , Alessandro Prigione

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

bioRxiv · Jul 8, 2024 · PreprintNeuroscience