Author

Leland Barnard

Regeneron (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 3 Organism:human· 3 Assay:electronic health records· 2 Approach:statistical model· 2 Assay:clinical cohort / trial· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:eQTL / molecular QTL mapping· 1

Frequent Co-Authors

Aris BarasiD· 3 shared Evan K. MaxwelliD· 3 shared Gonçalo R. AbecasisiD· 3 shared Jeffrey G. ReidiD· 3 shared Lukas Habegger· 3 shared Alan R. ShuldineriD· 2 shared Alexander E. LopeziD· 2 shared Alicia C. Hawes· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Aris BarasORCID

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Author profile →

3 papers

Recent·Most cited

Computationally efficient whole genome regression for quantitative and binary traits

Joelle S. Mbatchou, Leland Barnard, Joshua Backman, Anthony Marcketta, Jack A. Kosmicki, Andrey Ziyatdinov, Christian Benner, Colm T. O’Dushlaine, Mathew Barber, Boris Boutkov, Lukas Habegger, Manuel A. R. Ferreira, Aris Baras, Jeffrey G. Reid, Gonçalo R. Abecasis, , Jonathan Marchini

The paper introduces REGENIE, a fast whole genome regression method for quantitative and binary traits, showing computational efficiency and accuracy on UK Biobank data.

Nature Genetics · May 20, 2021Peer-reviewedGenetics

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

Marijana Vujković, Jacob M. Keaton, Julie Ann Lynch, Donald R. Miller, Jin J. Zhou, Catherine Tcheandjieu, Jennifer E. Huffman, Themistocles L. Assimes, Kimberly Lorenz, Xiang Zhu, Austin T. Hilliard, Renae Judy, Jie Huang, Kyung Min Lee, Derek M. Klarin, , Saib S. Gappy

Multi-ethnic type 2 diabetes (T2D) meta-analysis of 228,499 cases and 1,178,783 controls finds 318 previously unreported loci, 804 expression-colocalized genes, and 13 SNP-by-T2D vascular-outcome interactions.

Nature Genetics · Jun 15, 2020Peer-reviewedGenetic & Genomic Medicine✦ In-depth digest

Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank

Cristopher V. Van Hout, Ioanna Tachmazidou, Joshua Backman, Joshua X. Hoffman, Bin Ye, Ashutosh K. Pandey, Claudia G. Gonzaga-Jauregui, Shareef Khalid, Daren Liu, Nilanjana Banerjee, Alexander H. Li, O’Dushlaine Colm, Anthony Marcketta, Jeffrey C. Staples, Claudia Schurmann, , Aris Baras

Exomes of 49,960 UK Biobank participants reveal 231,631 predicted loss-of-function variants (>10-fold more than imputed data); burden tests implicate PIEZO1, MEPE, and COL6A1 in disease traits.

bioRxiv · Mar 9, 2019 · PreprintGenomics✦ In-depth digest