Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies
Runa I. Løberg, Helena A. Abdi-Dezfuli, Liv Kleppa, Alisa E. Dewan, Maureen Tania Meling, Ludvig Magne Sollid, M. Fleur du Pré
The paper shows that IEC-derived TG2-DGP fusion protein drives anti-TG2 autoantibody production in celiac disease.
bioRxiv · Sep 6, 2026 · PreprintImmunology