Cell BiologybioRxivPreprint
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes
Delong Li, Wenxin Zhang, Michaela Medina…·Florian Wilfling
This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.