Author

Felix Kraus

Harvard UniversityORCID 0000-0002-3757-541XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:microscopy & imaging analysis· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Florian WilflingiD· 3 shared J. Wade HarperiD· 3 shared Delong LiiD· 2 shared João A. PauloiD· 2 shared Johann BrenneriD· 2 shared Steven P. GygiiD· 2 shared Yizhi JiangiD· 2 shared Agustina Conrrero· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

Florian WilflingORCID

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Author profile →

4 papers

Recent·Most cited

Single-Cell proteomics discerns patient-specific subpopulations in pediatric B-cell acute lymphoblastic leukemia

Farah Jayousi, Felix Kraus, Agustina Conrrero, Jonathan W. Bush, Audi Setiadi, Philipp F. Lange

This study uses single-cell proteomics to identify patient-specific subpopulations in pediatric B-ALL, revealing relapse-prone phenotypes and potential for personalized therapy.

bioRxiv · Aug 28, 2026 · PreprintCancer Biology

A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical and dopaminergic-like induced neurons

Felix Kraus, Yuchen He, Yizhi Jiang, Delong Li, Yohannes Abere Ambaw, Federico M. Gasparoli, João A. Paulo, Tobias C. Walther, Robert V. Farese, Steven P. Gygi, Florian Wilfling, J. Wade Harper

The paper develops a human stem cell toolkit for studying lysosomal storage disorders by generating proteomic data from induced cortical and dopaminergic-like neurons.

Proceedings of the National Academy of Sciences · Jul 1, 2026Peer-reviewedCell Biology

Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes

Delong Li, Wenxin Zhang, Michaela Medina, Jan F. M. Stuke, Andre Schwarz, Jonas Brill, Johann Brenner, Felix Kraus, Simon Ohlerich, Javier Lizarrondo, Jeremy Pflaum, Julia H Grass, Lena-Marie Soltow, Dietmar Hammerschmid, Natalie Weber, , Florian Wilfling

This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.

bioRxiv · Jan 19, 2026 · PreprintCell Biology

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

Felix Kraus, Yuchen He, Sharan Swarup, Katherine A. Overmyer, Yizhi Jiang, Johann Brenner, Cristina Capitanio, Anna Bieber, Annie Jen, Nicole M. Nightingale, Benton J. Anderson, Chan Lee, João A. Paulo, Ian R.L. Smith, Jürgen M. Plitzko, , J. Wade Harper

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

Science Advances · Jan 22, 2025Peer-reviewedCell Biology