Wenxin Zhang

Probing intracellular physical environments by rotational and translational single-particle tracking

This paper introduces a method combining rotational and translational single-particle tracking to analyze nanoscale dynamics, showing it reveals distinct biophysical features of cellular compartments.

Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes

This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.

ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair

The paper shows ATG9A and ARFIP2 work together to regulate PI4P levels for lysosomal repair during damage and bacterial infection.

Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution

This study uses in vitro reconstitution to investigate ATG8 protein localization and cargo recruitment on phagophore membranes, revealing their roles in membrane expansion and bending.

Epigenetic Effects of Assisted Reproductive Technology in Human Offspring

This study examines the epigenetic effects of assisted reproductive technologies on human offspring, finding that certain procedures introduce DNA methylation changes linked to long-term health risks.