Andre Schwarz

This study shows that LLOMe forms amyloid structures inside lysosomes that mechanically rupture the lysosomal membrane, revealing a structural mechanism for lysosomal damage.

This paper introduces a combined MSI and cryo-ET pipeline for reliable single-cell classification in cryo-ET samples, enabling post-acquisition cell identification and classification.

The paper determines the in situ structure of mitochondrial ATP synthase in Polytomella algae using electron cryo-tomography, revealing six rotary positions and 21 substates of the F1 head.

This study uses cryo electron tomography and simulations to analyze the structure of SARS-CoV-2 spike protein in situ, revealing three hinges in the stalk domain that enable orientational flexibility.