Author

Lennie Chen

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Research Focus:variant calling· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Assay:long-read sequencing· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alec P. PankowiD· 4 shared Ben MurrelliD· 4 shared Carolyn E. WilliamsoniD· 4 shared Dylan H. WestfalliD· 4 shared James I. MullinsiD· 4 shared Morgane RollandiD· 4 shared Anna YsseliD· 3 shared Craig A. MagaretiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

Alec P. PankowORCID

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Author profile →

4 papers

Recent·Most cited

Long-Read Deep Sequencing Reveals High Rates of Multilineage Transmission and Rapid Viral Population Changes in Acute HIV Infection

James I. Mullins, Wenjie Deng, Elena E. Giorgi, Craig A. Magaret, Morgane Rolland, Tanmoy Bhattacharya A, Dylan H. Westfall, Anna Yssel, Roger E. Bumgarner, Ben Murrell, Thumbi Ndung’u, Merlin Lee Robb, Raabya Rossenkhan, Paul T. Edlefsen, Krista L. Dong, , Carolyn E. Williamson

The paper uses long-read sequencing to study HIV transmission and population dynamics in acute infection, finding high multilineage transmission rates and rapid viral evolution.

Nature Communications · May 25, 2026Peer-reviewedMicrobiology

Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials

Carolyn E. Williamson, Chivonne Moodley, Craig A. Magaret, Elena E. Giorgi, Morgane Rolland, Dylan H. Westfall, Anna Yssel, Wenjie Deng, Raabya Rossenkhan, Nonhlanhla N. Mkhize, Lennie Chen, Hong Zhao, Tanmoy Bhattacharya A, Alec P. Pankow, Ben Murrell, , James I. Mullins

The paper analyzes HIV breakthrough virus populations in antibody-mediated prevention trials, finding high rates of multilineage infections and recombination under VRC01 treatment.

Nature Communications · Apr 3, 2026Peer-reviewedMolecular Biology

VRC01 Selects Rare HIV Escape Mutations After Acquisition in Antibody-Mediated Prevention Trials

Carolyn E. Williamson, Lyle Curry, Nonhlanhla N. Mkhize, Elena E. Giorgi, Craig A. Magaret, Bronwen E. Lambson, Sinethemba Bhebhe, Haajira Kaldine, Thandeka Moyo-Gwete, Morgane Rolland, Raabya Rossenkhan, Nina Marie G. Garcia, Chivonne Moodley, Anna Yssel, Yunda Huang, , James I. Mullins

This study identifies VRC01-mediated viral escape mutations in HIV-infected participants from antibody-mediated prevention trials, showing that VRC01 can select for escape variants with cross-resistance to other CD4bs bnAbs.

bioRxiv · Oct 29, 2025 · PreprintMicrobiology

Optimized SMRT-UMI protocol produces highly accurate sequence datasets from diverse populations - application to HIV-1 quasispecies

Dylan H. Westfall, Wenjie Deng, Alec P. Pankow, Hugh Murrell, Lennie Chen, Hong Chao Zhao, Carolyn E. Williamson, Morgane Rolland, Ben Murrell, James I. Mullins

The paper presents an optimized SMRT-UMI protocol and bioinformatics pipeline to generate highly accurate sequence datasets from diverse pathogens, demonstrated on HIV-1 quasispecies.

Virus Evolution · Jan 1, 2024Peer-reviewedMolecular Biology