Yunda Huang

The paper develops a mechanistic model of vaccine-induced humoral responses, showing class-specific activation and competition among B cells, with stronger competition within classes.

The paper analyzes HIV breakthrough virus populations in antibody-mediated prevention trials, finding high rates of multilineage infections and recombination under VRC01 treatment.

This study identifies VRC01-mediated viral escape mutations in HIV-infected participants from antibody-mediated prevention trials, showing that VRC01 can select for escape variants with cross-resistance to other CD4bs bnAbs.

The paper identifies a new broadly neutralizing antibody, 04_A06, with high potency and breadth against HIV-1 strains, showing potential for prevention and therapy.

The paper benchmarks 49 algorithms for predicting B. pertussis vaccination outcomes, finding that purpose-built models outperform literature-based ones due to better handling of nonlinearities and data preprocessing.

The paper compares two approaches for predicting HIV-1 neutralization by combination antibody regimens, finding the combine-then-predict approach superior for binary outcomes and at least as good for continuous outcomes.