Author

Sinethemba Bhebhe

National Health Laboratory Service

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:DNA methylation· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Haajira KaldineiD· 3 shared Nonhlanhla N. MkhizeiD· 3 shared Penny L. MooreiD· 3 shared Peter B. GilbertiD· 3 shared Yunda HuangiD· 3 shared Alec P. PankowiD· 2 shared Allan C. deCampiD· 2 shared Anna YsseliD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Haajira KaldineORCID

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Author profile →

3 papers

Recent·Most cited

Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials

Carolyn E. Williamson, Chivonne Moodley, Craig A. Magaret, Elena E. Giorgi, Morgane Rolland, Dylan H. Westfall, Anna Yssel, Wenjie Deng, Raabya Rossenkhan, Nonhlanhla N. Mkhize, Lennie Chen, Hong Zhao, Tanmoy Bhattacharya A, Alec P. Pankow, Ben Murrell, , James I. Mullins

The paper analyzes HIV breakthrough virus populations in antibody-mediated prevention trials, finding high rates of multilineage infections and recombination under VRC01 treatment.

Nature Communications · Apr 3, 2026Peer-reviewedMolecular Biology

VRC01 Selects Rare HIV Escape Mutations After Acquisition in Antibody-Mediated Prevention Trials

Carolyn E. Williamson, Lyle Curry, Nonhlanhla N. Mkhize, Elena E. Giorgi, Craig A. Magaret, Bronwen E. Lambson, Sinethemba Bhebhe, Haajira Kaldine, Thandeka Moyo-Gwete, Morgane Rolland, Raabya Rossenkhan, Nina Marie G. Garcia, Chivonne Moodley, Anna Yssel, Yunda Huang, , James I. Mullins

This study identifies VRC01-mediated viral escape mutations in HIV-infected participants from antibody-mediated prevention trials, showing that VRC01 can select for escape variants with cross-resistance to other CD4bs bnAbs.

bioRxiv · Oct 29, 2025 · PreprintMicrobiology

Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy

Lutz Gieselmann, Andrew T. DeLaitsch, Malena Rohde, Henning Gruell, Christoph Kreer, Meryem Seda Ercanoglu, Harry B. Gristick, Philipp Schommers, Elvin Ahmadov, Caelan E. Radford, Andrea Mazzolini, Lily Zhang, Anthony P. West, Johanna Worczinski, Anna Momot, , Florian Klein

The paper identifies a new broadly neutralizing antibody, 04_A06, with high potency and breadth against HIV-1 strains, showing potential for prevention and therapy.

bioRxiv · Aug 27, 2025 · PreprintImmunology