Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction
Paul Deveau, Leo Colmet Daage, Derek Oldridge, Virginie Bernard, Angela Bellini, Mathieu Chicard, Nathalie Clement, Eve Lapouble, Valérie Combaret, Anne Boland, Vincent Meyer, Jean-François Deleuze, Isabelle Janoueix-Lerosey, Emmanuel Barillot, Olivier Delattre, , Valentina Boeva
The paper introduces QuantumClone, a method for clonal reconstruction in cancer that accounts for variant allele frequencies and genotypes, and applies it to neuroblastoma samples to identify recurrently altered pathways in different clonal populations.
bioRxiv · May 19, 2016Cancer Biology