Olivier Delattre

Oncogenic fusions induce an extensive cancer-restricted cryptic proteome in Ewing sarcoma

The paper shows EWSR1::FLI1 fusion drives the production of cancer-specific neoproteins in Ewing sarcoma, revealing a reversible dark proteome with therapeutic potential.

Specific killing of Ewing sarcoma by TCR-T cells targeting public neogene-encoded antigens

The paper demonstrates that TCR-T cells targeting neogene-encoded antigens can specifically kill Ewing sarcoma cells in vitro and in vivo.

The ITCC-P4 PDX platform of pediatric cancers for preclinical testing

The paper introduces a PDX platform for pediatric cancers, providing in vivo drug testing models and molecular data to aid in therapy development.

Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk

This study identifies 14 susceptibility loci for Ewing sarcoma through a genome-wide association meta-analysis, revealing genetic interactions with somatic EWSR1::FLI1 fusions.

Label-free Machine Learning Prediction of Chemotherapy on Tumor Spheroids using a Microfluidics Droplet Platform

This paper develops a label-free platform combining microfluidics, morphological analysis, and machine learning to predict chemotherapy effects on tumor spheroids, showing robust performance across cell lines and patient-derived samples.

Dynamic oncogene activity metabolically reprograms the tryptophan-kynurenine-AHR axis driving immune evasion and tumor progression in Ewing sarcoma

This study shows that reduced EWSR1::ETS activity in Ewing sarcoma promotes immune evasion via the tryptophan-kynurenine-AHR axis, leading to worse clinical outcomes and tumor progression.

Super-enhancer-driven CACNA2D2 is an EWSR1::WT1 signature gene encoding a diagnostic marker for desmoplastic small round cell tumor (DSRCT)

The paper identifies CACNA2D2 as a super-enhancer-driven target of EWSR1::WT1 and demonstrates its utility as a diagnostic biomarker for DSRCT.

The pelvic organs receive no parasympathetic innervation

The paper uses single-cell RNA sequencing to show that the mouse pelvic ganglion contains neurons distinct from both sympathetic and parasympathetic types, and that pelvic organs are innervated by a divergent sympathetic pathway, not parasympathetic or typical sympathetic neurons.

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation

The paper presents a multi-omics cell line atlas for Ewing sarcoma, identifying new target genes and regulatory mechanisms of EWSR1-ETS fusion oncogenes.

transmorph: a unifying computational framework for single-cell data integration

transmorph provides a flexible framework for single-cell data integration, enabling complex pipelines and demonstrating its utility in various integration tasks.

Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction

The paper introduces QuantumClone, a method for clonal reconstruction in cancer that accounts for variant allele frequencies and genotypes, and applies it to neuroblastoma samples to identify recurrently altered pathways in different clonal populations.