Islet amyloid disrupts MHC Class II antigen presentation and protects NOD mice from autoimmune diabetes.
Heather C. Denroche, Victoria Ng, Jane Velghe, Imelda W. Suen, Liam Stanley, Dominika Nąckiewicz, Mitsuhiro Komba, Derek L. Dai, Galina Soukhatcheva, Sam Chen, C. Bruce Verchere
This study shows that islet amyloid disrupts MHC Class II antigen presentation in islet macrophages, protecting NOD mice from autoimmune diabetes by reducing immune cell infiltration and antigen-specific T cell activation.
Diabetologia · Dec 22, 2025Peer-reviewedImmunology