Author

Derek L. Dai

University of British Columbia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Galina SoukhatchevaiD· 3 shared C. Bruce VerchereiD· 2 shared Mitsuhiro KombaiD· 2 shared Abraham Stijn MeijnikmaniD· 1 shared Arnold W. J. M. van de LaariD· 1 shared Bert‐Jan H. van den BorniD· 1 shared Bruce Andrew VallanceiD· 1 shared Caixia MaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

Galina SoukhatchevaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Autophagy protects pancreatic β-cells during hypoxia and islet transplantation but is compromised by TFEB-lysosomal dysfunction

Yuanjie Zou, Daniel J. Pasula, Renmei Tang, Mitsuhiro Komba, Derek L. Dai, Galina Soukhatcheva, Cameron Bruce Verchere, Dan S. Luciani

bioRxiv · Jul 3, 2026 · PreprintCell Biology

Islet amyloid disrupts MHC Class II antigen presentation and protects NOD mice from autoimmune diabetes.

Heather C. Denroche, Victoria Ng, Jane Velghe, Imelda W. Suen, Liam Stanley, Dominika Nąckiewicz, Mitsuhiro Komba, Derek L. Dai, Galina Soukhatcheva, Sam Chen, C. Bruce Verchere

This study shows that islet amyloid disrupts MHC Class II antigen presentation in islet macrophages, protecting NOD mice from autoimmune diabetes by reducing immune cell infiltration and antigen-specific T cell activation.

Diabetologia · Dec 22, 2025Peer-reviewedImmunology

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

Torsten P. M. Scheithauer, Hilde Herrema, Hongbing Yu, Guido J. Bakker, Maaike Winkelmeijer, Galina Soukhatcheva, Derek L. Dai, Caixia Ma, Stefan R. Havik, Manon Balvers, Mark Davids, Abraham Stijn Meijnikman, Ömrüm Aydin, Bert‐Jan H. van den Born, Marc G. Besselink, , Daniël H. van Raalte

This study shows that gut-derived bacterial flagellin contributes to beta-cell inflammation and dysfunction in type 2 diabetes.

Gut Microbes · Aug 19, 2022Peer-reviewedMolecular Biology